Reciprocal interactions of obstructive sleep apnea and hypertension associated with ACE I/D polymorphism in males

Reciprocal interactions of obstructive sleep apnea and hypertension associated with ACE I/D polymorphism in males

Author Koyama, Renata G. Autor UNIFESP Google Scholar
Drager, Luciano F. Google Scholar
Lorenzi-Filho, Geraldo Google Scholar
Cintra, Fatima D. Autor UNIFESP Google Scholar
Pereira, Alexandre C. Google Scholar
Poyares, Dalva Autor UNIFESP Google Scholar
Krieger, Jose Eduardo Google Scholar
Castro, Rosa M. R. P. S. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Pedrazzoli, Mario Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Background: the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism gene contributes to the genesis of hypertension (HTN) and may help explain the relationship between obstructive sleep apnea (OSA) and HTN. However, ACE is a pleiotropic gene that has several influences, including skeletal muscle and control of ventilation. We therefore tested the hypothesis that ACE polymorphism influences OSA severity.Methods: Male OSA patients (apnea-hypopnea index [AHI] > 5 events/h) from 2 university sleep centers were evaluated by polysomnography and ACE I/D polymorphism genotyping.Results: We studied 266 males with OSA (age = 48 +/- 13y, body mass index = 29 5kg/m(2), AHI = 34 +/- 25events/h). HTN was present in 114 patients (43%) who were older (p < 0.01), heavier (p < 0.05) and had more severe OSA (p < 0.01). the I allele was associated with HTN in patients with mild to moderate OSA (p < 0.01), but not in those with severe OSA. ACE I/D polymorphism was not associated with apnea severity among normotensive patients. in contrast. the only variables independently associated with OSA severity among patients with hypertension in multivariate analysis were BMI (OR = 1.12) and 11 genotype (OR = 0.27).Conclusions: Our results indicate reciprocal interactions between OSA and HTN with ACE I/D polymorphism, suggesting that among hypertensive OSA males, the homozygous ACE I allele protects from severe OSA. (C) 2009 Elsevier B.V. All rights reserved.
Keywords Obstructive sleep apnea
Hypertension
ACE gene
ACE I/D polymorphism
Genetics
Gene-environment interaction
Language English
Date 2009-12-01
Published in Sleep Medicine. Amsterdam: Elsevier B.V., v. 10, n. 10, p. 1107-1111, 2009.
ISSN 1389-9457 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1107-1111
Origin http://dx.doi.org/10.1016/j.sleep.2008.12.012
Access rights Closed access
Type Article
Web of Science ID WOS:000272763800008
URI http://repositorio.unifesp.br/handle/11600/31996

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