Acute cognitive effects of donepezil in young, healthy volunteers

Acute cognitive effects of donepezil in young, healthy volunteers

Author Zaninotto, Ana L. C. Autor UNIFESP Google Scholar
Bueno, Orlando F. A. Autor UNIFESP Google Scholar
Pradella-Hallinan, Marcia Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Rusted, Jenny Google Scholar
Stough, Con Google Scholar
Pompeia, Sabine Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Sussex
Swinburne Univ Technol
Abstract Objective the acute nootropic potential of donepezil in young healthy volunteers has not been adequately investigated mainly because in previous studies: (1) effects were assessed before peak-plasma concentration (Tmax) was reached; (2) only a few cognitive processes were assessed. Here we investigated a myriad of cognitive effects of augmentation of acetylcholine using an acute dose of donepezil in healthy adults at theoretical Tmax.Methods This was a double-blind, placebo controlled, parallel group design study of cognitive effects of acute oral donepezil (5 mg). Subjects were tested twice after donepezil ingestion: 90 min (time that coincides with previous testing in the literature) and 210 min. (theoretical Tmax). the test battery included tasks that tap cognitive domains that are sensitive to acetylcholine manipulations.Results At both testing times donepezil improved long-term recall of prose, objects recall, recall of spatial locations, and integration of objects with their locations, some effects having been related to self-reported mood enhancement. However, improvement of performance in the central executive measure (backward digit span) occurred only at Tmax.Conclusion Positive cognitive effects of acute donepezil can be observed in various cognitive domains including mood, but its full nootropic potential is more clearly found close to theoretical peak-plasma concentration. Copyright (C) 2009 John Wiley & Sons, Ltd.
Keywords donepezil
acetylcholinesterase inhibitor
working memory
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2005/03330-5
FAPESP: 1998/14303-3
Date 2009-08-01
Published in Human Psychopharmacology-clinical and Experimental. Chichester: John Wiley & Sons Ltd, v. 24, n. 6, p. 453-464, 2009.
ISSN 0885-6222 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 453-464
Access rights Closed access
Type Article
Web of Science ID WOS:000269175400003

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