L-Arginine Supplementation Protects Against Hepatic Ischemia-Reperfusion Lesions in Rabbits

L-Arginine Supplementation Protects Against Hepatic Ischemia-Reperfusion Lesions in Rabbits

Author Taha, M. O. Autor UNIFESP Google Scholar
Simoes, M. J. Autor UNIFESP Google Scholar
Haddad, M. A. Autor UNIFESP Google Scholar
Capelato, R. C. Google Scholar
Budny, N. Google Scholar
Matsumoto, A. H. Google Scholar
Soares, P. C. M. Google Scholar
Santos, W. M. Google Scholar
Armeato, G. D. Google Scholar
Araki, C. M. Google Scholar
Gomes, J. S. M. Autor UNIFESP Google Scholar
Magalhaes, K. G. Autor UNIFESP Google Scholar
Tersariol, I. L. S. Google Scholar
Monteiro, H. P. Autor UNIFESP Google Scholar
Oliveira, I. Autor UNIFESP Google Scholar
Jurkiewicz, A. Autor UNIFESP Google Scholar
Caricati-Neto, A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fed Univ Grande Dourados
Univ Mogi Cruzws
Abstract We evaluated the effects of a substrate in the biosynthesis of nitric oxide (NO)-L-arginine (LARG)-on hepatic lesions caused by ischemia/reperfusion (I/R) injury in rabbit livers. Rabbits were pretreated with LARG (150 mg/kg IV) or saline solution 0.9% (SS) before the hepatic I/R procedure. the effects of LARG on hepatic injury were evaluated before and after I/R. the warm hepatic I/R procedure produced profound acute liver injury, as indicated by elevated values of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactic dehydrogenase (LDH), as well as a high apoptotic cell count. All changes were attenuated by treatment with LARG before the hepatic I/R procedure. These results suggested that LARG produced protective effects on hepatic I/R lesions. This protective effect of LARG was probably associated with blocking generation of superoxide anions during the hepatic I/R procedure.
Language English
Date 2009-04-01
Published in Transplantation Proceedings. New York: Elsevier B.V., v. 41, n. 3, p. 816-819, 2009.
ISSN 0041-1345 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 816-819
Origin http://dx.doi.org/10.1016/j.transproceed.2009.02.050
Access rights Closed access
Type Article
Web of Science ID WOS:000265504300009
URI http://repositorio.unifesp.br/handle/11600/31429

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