Reduced schedule of human anti-rabies immunization with Fuenzalida & Palacios vaccine: additional data

Reduced schedule of human anti-rabies immunization with Fuenzalida & Palacios vaccine: additional data

Alternative title Esquema reduzido de imunização anti-rábica humana com vacina Fuenzalida & Palacios: dados adicionais
Author Favoretto, S.r. Google Scholar
Carrieri, M.l. Google Scholar
Tino, M.s. Autor UNIFESP Google Scholar
Assis, A. Google Scholar
Zanetti, C.r. Google Scholar
Pereira, O.a.c. Google Scholar
Institution Instituto Pasteur de São Paulo
Universidade Federal de São Paulo (UNIFESP)
Secretaria de Agricultura, Abastec. e Meio Ambiente de Mogi-Guaçu
Abstract It was reevaluated a reduced schedule for anti-rabies post-exposure immunization with newborn mice nervous tissue vaccine (Fuenzalida 8c Palacios) in a group of 30 non exposed volunteers. The vaccine was administered by intramuscular injections on days zero, 2, 4, 16 and 27, in the deltoid area. Antibody levels were determinated by a simplified serum neutralization microtest on days zero, 16 and 37. On days 16 and 37 the antibody levels of the whole group was >0.5 IU/ml and >1.0 IU/ml, respectively. The cell mediated immunity was precociously detected (on day 4) by the delayed type hipersensitivity skin test. Our results show that this reduced schedule elicited an early and effective humoral and cellular immune response. However it is necessary other studies with larger groups of vaccinees in order to obtain definitive conclusion.

Foi reestudado em um grupo adicional de 30 voluntários não expostos ao contágio um esquema reduzido para imunização pós-exposi-ção com vacina de sistema nervoso de camundongos recém-nascidos (Fuenzalida ; Palacios). A vacina foi administrada nos dias zero, 2, 4, 16 e 27. A resposta imune humoral foi avaliada por soroneutralização em cultura celular nos dias zero, 16 e 37. Já no dia 16 os títulos de anticorpos foram > 0.5 UI/ml e no dia 37 > 1.00 UI/ml. A resposta imune celular foi avaliada no dia 4 pelo teste cutâneo de hipersensibilidade tardia. Foram obtidos resultados positivos em todos os 30 voluntários estudados.
Keywords Human Anti-rabies Immunization
Reduced Schedule
Humoral and cellular immune responses
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 1993-06-01
Published in Revista do Instituto de Medicina Tropical de São Paulo. Instituto de Medicina Tropical, v. 35, n. 3, p. 281-284, 1993.
ISSN 0036-4665 (Sherpa/Romeo)
Publisher Instituto de Medicina Tropical
Extent 281-284
Access rights Open access Open Access
Type Article
SciELO ID S0036-46651993000300010 (statistics in SciELO)

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