Alteration of purinergic P2X(4) and P2X(7) receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine

Doná, Flávia; Ulrich, Henning; Persike, Daniele Suzete; Conceição, Isaltino Marcelo da; Blini, João Paulo; Cavalheiro, Esper Abrão; Silva Fernandes, Maria Jose

doi:10.1016/j.eplepsyres.2008.10.008

dc.contributor.author	Doná, Flávia [UNIFESP]
dc.contributor.author	Ulrich, Henning
dc.contributor.author	Persike, Daniele Suzete [UNIFESP]
dc.contributor.author	Conceição, Isaltino Marcelo da [UNIFESP]
dc.contributor.author	Blini, João Paulo [UNIFESP]
dc.contributor.author	Cavalheiro, Esper Abrão [UNIFESP]
dc.contributor.author	Silva Fernandes, Maria Jose [UNIFESP]
dc.date.accessioned	2016-01-24T13:52:14Z
dc.date.available	2016-01-24T13:52:14Z
dc.date.issued	2009-02-01
dc.identifier	http://dx.doi.org/10.1016/j.eplepsyres.2008.10.008
dc.identifier.citation	Epilepsy Research. Amsterdam: Elsevier B.V., v. 83, n. 2-3, p. 157-167, 2009.
dc.identifier.issn	0920-1211
dc.identifier.uri	http://repositorio.unifesp.br/handle/11600/31294
dc.description.abstract	Although ATP and P2X receptor activity have been lately associated with epilepsy, little is known regarding their exact roles in epileptogenesis. Temporal-lobe epilepsy (TLE) in rat was induced by pilocarpine in order to study changes of hippocampal P2X(2), P2X(4) and P2X(7) receptor expression during acute, latent or chronic phases of epilepsy. During acute and chronic phases increased P2X(7) receptor expression was principally observed in glial cells and glutamatergic nerve terminals, suggesting participation of this receptor in the activation of inflammatory and excitotoxic processes during epileptogenesis. No significant alterations of hippocampal P2X(2) and P2X(4) receptor expression was noted during the acute or latent phase when compared to the control group, indicating that these receptors are not directly involved with the initiation of epilepsy. However, the reduction of hippocampal P2X(4) receptor immunostaining in the chronic phase could reflect neuronal toss or decreased GABAergic signaling. (C) 2008 Elsevier B.V. All rights reserved.	en
dc.description.sponsorship	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent	157-167
dc.language.iso	eng
dc.publisher	Elsevier B.V.
dc.relation.ispartof	Epilepsy Research
dc.rights	Acesso restrito
dc.subject	Epilepsy	en
dc.subject	P2X receptor	en
dc.subject	ATP	en
dc.subject	Hippocampus	en
dc.subject	Pilocarpine	en
dc.subject	Rat	en
dc.title	Alteration of purinergic P2X(4) and P2X(7) receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine	en
dc.type	Artigo
dc.rights.license	http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution	Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution	Universidade de São Paulo (USP)
dc.contributor.institution	Inst Butantan
dc.description.affiliation	Universidade Federal de São Paulo, Dept Neurol Neurocirurg, Discipline Neurol Expt, UNIFESP, BR-04023900 São Paulo, Brazil
dc.description.affiliation	Univ São Paulo, Inst Quim, Dept Bioquim, São Paulo, Brazil
dc.description.affiliation	Inst Butantan, Farmacol Lab, São Paulo, Brazil
dc.description.affiliationUnifesp	Universidade Federal de São Paulo, Dept Neurol Neurocirurg, Discipline Neurol Expt, UNIFESP, BR-04023900 São Paulo, Brazil
dc.identifier.doi	10.1016/j.eplepsyres.2008.10.008
dc.description.source	Web of Science
dc.identifier.wos	WOS:000263818400009