Alteration of purinergic P2X(4) and P2X(7) receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine

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dc.contributor.author Doná, Flávia [UNIFESP]
dc.contributor.author Ulrich, Henning
dc.contributor.author Persike, Daniele Suzete [UNIFESP]
dc.contributor.author Conceição, Isaltino Marcelo da [UNIFESP]
dc.contributor.author Blini, João Paulo [UNIFESP]
dc.contributor.author Cavalheiro, Esper Abrão [UNIFESP]
dc.contributor.author Silva Fernandes, Maria Jose [UNIFESP]
dc.date.accessioned 2016-01-24T13:52:14Z
dc.date.available 2016-01-24T13:52:14Z
dc.date.issued 2009-02-01
dc.identifier http://dx.doi.org/10.1016/j.eplepsyres.2008.10.008
dc.identifier.citation Epilepsy Research. Amsterdam: Elsevier B.V., v. 83, n. 2-3, p. 157-167, 2009.
dc.identifier.issn 0920-1211
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31294
dc.description.abstract Although ATP and P2X receptor activity have been lately associated with epilepsy, little is known regarding their exact roles in epileptogenesis. Temporal-lobe epilepsy (TLE) in rat was induced by pilocarpine in order to study changes of hippocampal P2X(2), P2X(4) and P2X(7) receptor expression during acute, latent or chronic phases of epilepsy. During acute and chronic phases increased P2X(7) receptor expression was principally observed in glial cells and glutamatergic nerve terminals, suggesting participation of this receptor in the activation of inflammatory and excitotoxic processes during epileptogenesis. No significant alterations of hippocampal P2X(2) and P2X(4) receptor expression was noted during the acute or latent phase when compared to the control group, indicating that these receptors are not directly involved with the initiation of epilepsy. However, the reduction of hippocampal P2X(4) receptor immunostaining in the chronic phase could reflect neuronal toss or decreased GABAergic signaling. (C) 2008 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 157-167
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Epilepsy Research
dc.rights Acesso restrito
dc.subject Epilepsy en
dc.subject P2X receptor en
dc.subject ATP en
dc.subject Hippocampus en
dc.subject Pilocarpine en
dc.subject Rat en
dc.title Alteration of purinergic P2X(4) and P2X(7) receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Inst Butantan
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol Neurocirurg, Discipline Neurol Expt, UNIFESP, BR-04023900 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Inst Quim, Dept Bioquim, São Paulo, Brazil
dc.description.affiliation Inst Butantan, Farmacol Lab, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol Neurocirurg, Discipline Neurol Expt, UNIFESP, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/j.eplepsyres.2008.10.008
dc.description.source Web of Science
dc.identifier.wos WOS:000263818400009



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