Modulation of operational lung volumes with the use of salbutamol in COPD patients accomplishing upper limbs exercise tests

Modulation of operational lung volumes with the use of salbutamol in COPD patients accomplishing upper limbs exercise tests

Author Porto, Elias Ferreira Autor UNIFESP Google Scholar
Castro, Antônio Adolfo Mattos de Autor UNIFESP Google Scholar
Nascimento, Oliver Augusto Autor UNIFESP Google Scholar
Oliveira, Rosangela C. Autor UNIFESP Google Scholar
Cardoso, Fábio Autor UNIFESP Google Scholar
Jardim, José Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Adventist Univ
Univ Guarulhos
Abstract Introduction: Pulmonary dynamic hyperinflation (DH) is an important factor limiting the physical capacity of patients with COPD. Inhaled bronchodilator should be able to reduce DH.Objective: To measure DH in COPD patients during upper limbs exercise tests with previous use of bronchodilator or placebo, and to evaluate the respiratory pattern to justify the dynamics of hyperinflation.Methods: Inspiratory capacity (IC) of 16 patients with COPD (age: 63 13 years; FEV(1) of 1.5 +/- 0.7 L-41 +/- 11% predicted) was measured before and after an incremental arm exercise test (diagonal technique) with randomly and double-blinded inhaled placebo or salbutamol. Results: Rest IC increased from 2.32 +/- 0.44 L to 2.54 +/- 0.39 L after inhalation of 400 mcg of salbutamol. (p = 0.0012). There was a decrease in the IC after a maximal incremental arm exercise test, 222 +/- 158 ml. (p = 0.001) with placebo use, but no change was seen after the salbutamol use: 104 +/- 205 ml (p = 0.41); 62% of the patients presented a 10% or more reduction in the IC after the exercise with placebo. There was a correlation between DH and lower FEV(1)/FVC (p = 0.0067), FEV, predicted (p = 0.0091) and IC% predicted (p = 0.043) and higher VO(2) ml/Kg/min % predicted (p = 0.05). Minute ventilation and respiratory rate were higher during the exercise with placebo (p = 0.002) whereas VE/MVV ratio was tower in the exercise after salbutamol (p > 0.05).Conclusion: We conclude that the use of bronchodilator increases the IC of patient with COPD and may help not to increase the DH during a maximal. exercise with the arms. (C) 2008 Elsevier B.V. All rights reserved.
Keywords Upper limbs exercise
Dynamic hyperinflation
Salbutamol
COPD
Language English
Date 2009-02-01
Published in Respiratory Medicine. London: W B Saunders Co Ltd, v. 103, n. 2, p. 251-257, 2009.
ISSN 0954-6111 (Sherpa/Romeo, impact factor)
Publisher W B Saunders Co Ltd
Extent 251-257
Origin http://dx.doi.org/10.1016/j.rmed.2008.08.018
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000263187100014
URI http://repositorio.unifesp.br/handle/11600/31264

Show full item record




File

Name: WOS000263187100014.pdf
Size: 254.2Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account