Serum Ferritin Level Remains a Reliable Marker of Bone Marrow Iron Stores Evaluated by Histomorphometry in Hemodialysis Patients

Serum Ferritin Level Remains a Reliable Marker of Bone Marrow Iron Stores Evaluated by Histomorphometry in Hemodialysis Patients

Author Rocha, Lillian Andrade da Autor UNIFESP Google Scholar
Barreto, Daniela Veit Autor UNIFESP Google Scholar
Barreto, Fellype de Carvalho Autor UNIFESP Google Scholar
Dias, Cristiane Bitencourt Google Scholar
Moyses, Rosa Google Scholar
Silva, Maria Regina Regis da Autor UNIFESP Google Scholar
Moura, Luiz Antonio Ribeiro de Autor UNIFESP Google Scholar
Draibe, Sergio Antonio Autor UNIFESP Google Scholar
Jorgetti, Vanda Google Scholar
Carvalho, Aluizio Barbosa de Autor UNIFESP Google Scholar
Canziani, Maria Eugenia Fernandes Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Background and objectives: As well as being a marker of body iron stores, serum ferritin (sFerritin) has also been shown to be a marker of inflammation in hemodialysis (HD) patients. the aim of this study was to analyze whether sFerritin is a reliable marker of the iron stores present in bone marrow of HD patients.Design: Histomorphometric analysis of stored transiliac bone biopsies was used to assess iron stores by determining the number of iron-stained cells per square millimeter of bone marrow.Results: in 96 patients, the laboratory parameters were hemoglobin = 11.3 +/- 1.6 g/dl, hematocrit = 34.3 +/- 5%, sFerritin 609 +/- 305 ng/ml, transferrin saturation = 32.7 +/- 22.5%, and C-reactive protein (CRP) = 0.9 +/- 1.4 mg/dl. sFerritin correlated significantly with CRP, bone marrow iron, and time on HD treatment W = 0.006, 0.001, and 0.048, respectively). the independent determinants of sFerritin were CRP (beta-coef = 0.26; 95% CI = 24.6 to 132.3) and bone marrow iron (beta-coef = 0.32; 95% CI = 0.54 to 2.09). Bone marrow iron was higher in patients with sFerritin >500 ng/ml than in those with sFerritin :5500 ng/ml. in the group of patients with sFerritin :5500 ng/ml, the independent determinant of sFerritin was bone marrow iron (beta-coef = 0.48, 95% CI = 0.48 to 1.78), but in the group of patients with sFerritin >500 ng/ml, no independent determinant of sFerritin was found.Conclusions: sFerritin adequately reflects iron stores in bone marrow of HD patients.
Language English
Sponsor Genzyme Corporation, Carnbridge, Massachusetts, USA
Oswaldo Ramos Foundation, São Paulo, Brazil
Date 2009-01-01
Published in Clinical Journal of the American Society of Nephrology. Washington: Amer Soc Nephrology, v. 4, n. 1, p. 105-109, 2009.
ISSN 1555-9041 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Nephrology
Extent 105-109
Origin http://dx.doi.org/10.2215/CJN.01630408
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000262681200018
URI http://repositorio.unifesp.br/handle/11600/31130

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