Serotonin depletion effects on the pilocarpine model of epilepsy

Serotonin depletion effects on the pilocarpine model of epilepsy

Author Trindade-Filho, Euclides Mauricio Google Scholar
Castro-Neto, Eduardo Ferreira de Autor UNIFESP Google Scholar
Carvalho, Reinaldo de A. Autor UNIFESP Google Scholar
Lima, Eliangela Autor UNIFESP Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Amado, Debora Autor UNIFESP Google Scholar
Naffah-Mazzacoratti, Maria Da Graca Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Estadual Ciencias Saude Alagoas UNCISAL
Abstract The monoamine content in cerebral structures has been related to neuronal excitability and several approaches have been used to study this phenomenon during seizure vulnerability. in the present work, we have described the effects of serotonin (5-HT) depletion after the administration of 5,7-dihydroxytryptamine (5,7-DHT) into the median raphe nucleus in rats submitted to the pilocarpine model of epilepsy. Susceptibility to pilocarpine-induced status epilepticus as well as the spontaneous seizure frequency during the chronic period of the model was determined. Since the hippocampus is one of the main structures in the development of this epilepsy model, the 5-HT levels in this region were also determined after drug administration. Sixty-three percent of 5,7-DHT pre-treated rats (15/24) and only 33.4% of those receiving the control solution (9/24) progressed to motor limbic seizures evolving to status epilepticus, following the administration of pilocarpine. the frequency of seizures during the chronic period, in epileptic rats that received 5,7-DHT, showed a significant (58%) increase after the treatment, when compared with control group. Our data showed that serotonin may play an important role on seizure activity which seems to be exerted by its inhibitory action on the expression of overt behavior seizures departing from an established focus in the limbic system. (C) 2008 Elsevier B.V. All rights reserved.
Keywords Serotonin depletion
Epilepsy
Pilocarpine
5,7-Dihydroxytryptamine
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Programa de Apoio a Nucleo de Excelencia (PRONEX)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2008-12-01
Published in Epilepsy Research. Amsterdam: Elsevier B.V., v. 82, n. 2-3, p. 194-199, 2008.
ISSN 0920-1211 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 194-199
Origin http://dx.doi.org/10.1016/j.eplepsyres.2008.08.010
Access rights Closed access
Type Article
Web of Science ID WOS:000261941600012
URI http://repositorio.unifesp.br/handle/11600/31073

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