Is UCP2 Gene Polymorphism Associated With Decreased Resting Energy Expenditure in Nondialyzed Chronic Kidney Disease Patients?

Show simple item record

dc.contributor.author Avesani, Carla Maria [UNIFESP]
dc.contributor.author Kamimura, Maria Ayako [UNIFESP]
dc.contributor.author Uraka, Simone [UNIFESP]
dc.contributor.author Pecoits-Filho, Roberto
dc.contributor.author Nordfors, Louise
dc.contributor.author Stenvinkel, Peter
dc.contributor.author Lindholm, Bengt
dc.contributor.author Draibe, Sergio Antonio [UNIFESP]
dc.contributor.author Cuppari, Lilian [UNIFESP]
dc.date.accessioned 2016-01-24T13:51:52Z
dc.date.available 2016-01-24T13:51:52Z
dc.date.issued 2008-11-01
dc.identifier http://dx.doi.org/10.1053/j.jrn.2008.08.009
dc.identifier.citation Journal of Renal Nutrition. Philadelphia: W B Saunders Co-Elsevier Inc, v. 18, n. 6, p. 489-494, 2008.
dc.identifier.issn 1051-2276
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31018
dc.description.abstract Objective: the deletion/deletion (del/del) polymorphism of uncoupling protein 2 (UCP2) was associated with decreased energy expenditure in diabetic and obese patients. There is evidence of decreased resting energy expenditure (REE) in chronic kidney disease (CKD) patients not yet on dialysis. However, whether REE is associated with the UCP2 polymorphism was not previously investigated in this population. This study evaluated whether the del/del polymorphism of the UCP2 gene is associated with lower REE in nondialyzed CKD patients.Design: This was a cross-sectional study.Patients and Methods: Forty-four nondialyzed CKD patients (29 male; aged 52 12 years; creatinine clearance, 37 +/- 13 mL/min/1.73 m(2) [values are mean +/- SD unless otherwise noted]) were included. Their REE was assessed by indirect calorimetry, and body composition by bioelectrical impedance. High-sensitivity C-reactive protein (hs-CRP) was also evaluated. the insertion/deletion (ins/del) polymorphism of the UCP2 gene was determined in all participants. To test whether the deletion/deletion (del/del) polymorphism of the UCP2 gene was associated with lower REE, the REE of carriers of the del/del genotype (n = 24; group Del) was compared with that of carriers of the insertion and ins/del genotype (n = 20; group Ins).Main Outcome Measure: the main outcome measure was REE.Results: the REE of group Del was similar to that of the group Ins (1379 +/- 239 kcal/day vs. 1360 +/- 289 kcal/day, respectively, P = NS). This result was maintained even after the REE was adjusted for lean body mass by analysis of covariance. in addition, in a multiple-regression analysis using REE as the dependent variable, only lean body mass and hs-CRP were significant predictors of REE.Conclusion: the results suggest that the del/del polymorphism of the UCP2 gene is not associated with lower FEE in nondialyzed CKD patients. (C) 2008 by the National Kidney Foundation, Inc. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship undo de Auxilio aos Docente e Alunos da Universidade Federal de São Paulo
dc.description.sponsorship Oswaldo Ramos Foundation (Brazil)
dc.description.sponsorship Baxter Healthcare (Deerfield, IL)
dc.format.extent 489-494
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Journal of Renal Nutrition
dc.rights Acesso restrito
dc.title Is UCP2 Gene Polymorphism Associated With Decreased Resting Energy Expenditure in Nondialyzed Chronic Kidney Disease Patients? en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Karolinska Inst
dc.contributor.institution Pontificia Univ Catolica Parana
dc.description.affiliation Universidade Federal de São Paulo, Div Nephrol, Dept Med, BR-04039000 São Paulo, Brazil
dc.description.affiliation Karolinska Inst, Div Baxter Novum, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
dc.description.affiliation Karolinska Inst, Div Renal Med, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
dc.description.affiliation Universidade Federal de São Paulo, Postgrad Program Nutr, BR-04039000 São Paulo, Brazil
dc.description.affiliation Pontificia Univ Catolica Parana, Div Biol Sci & Hlth, Maringa, Parana, Brazil
dc.description.affiliation Karolinska Inst, Dept Mol Med, Stockholm, Sweden
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Nephrol, Dept Med, BR-04039000 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Postgrad Program Nutr, BR-04039000 São Paulo, Brazil
dc.identifier.doi 10.1053/j.jrn.2008.08.009
dc.description.source Web of Science
dc.identifier.wos WOS:000260916300003



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account