Deep anterior lamellar transplant using lyophilized and optisol corneas in patients with keratoconus

Deep anterior lamellar transplant using lyophilized and optisol corneas in patients with keratoconus

Author Farias, Roberta Autor UNIFESP Google Scholar
Barbosa, Luciene Autor UNIFESP Google Scholar
Lima, Acacio Google Scholar
Mayumi, Eliane Google Scholar
Lourenco, Andrea Google Scholar
Freitas, Denise de Autor UNIFESP Google Scholar
Allemann, Norma Google Scholar
Vieira, Luis Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Sorocaba Eye Bank
Abstract Purpose: Prospective randomized clinical trial to evaluate the efficacy of lyophilized corneas for deep anterior lamellar keratoplasty (DALK) in patients with keratoconus.Methods: Ten eyes underwent DALK and received corneas that had been lyophilized, and 10 eyes received corneas kept in Optisol. Follow-up examinations included measurement of visual acuity (VA; Early Treatment Diabetic Retiropathy Study chart), topography, pachymetry, specular microscopy, constrast sensitivity, and confocal micorscopy.Results: All vairables improved similarly in both groups, without statistical differences between them, except for the uncorrected VA in the sixth postoperative month, which was better in the lyophilized group (0.46) compared with Optisol group (0.70). the best spectacle-corrected VA was 0.16 in the lyophilized group and 0.26 in the Optisol group. the mean endothelial cell count during the sixth postoperative month was 2778.5 in the lyophilized group and 2611.5 in the Optisol group. Optisol corneas had greater keratocyte density, and the keratocyte density improved in lyophilized corneas during follow-up.Conclusion: Lyophilized corneas can be used successfully for DALK to treat keratoconus with results similar to Optisol corneas.
Keywords deep anterior lamellar keratoplasty
keratoconus
Optisol
lyophilization
Language English
Date 2008-10-01
Published in Cornea. Philadelphia: Lippincott Williams & Wilkins, v. 27, n. 9, p. 1030-1036, 2008.
ISSN 0277-3740 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 1030-1036
Origin http://dx.doi.org/10.1097/ICO.0b013e31817e903a
Access rights Closed access
Type Article
Web of Science ID WOS:000259662600011
URI http://repositorio.unifesp.br/handle/11600/30958

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