Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain

Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain

Author Paccola, Carina Cicconi Google Scholar
Gutierrez, Vanessa Pacciari Google Scholar
Longo, Ingrid Google Scholar
Juliano, Luiz Autor UNIFESP Google Scholar
Juliano, Maria Aparecida Autor UNIFESP Google Scholar
Giorgi, Renata Google Scholar
Institution Butantan Inst
Universidade Federal de São Paulo (UNIFESP)
Abstract The synthetic peptide identical to the C-terminus of murine S100A9 protein (mS100A9p) has antinociceptive effect on different acute inflammatory pain models. in this study, the effect of mS100A9p was investigated on neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve in rats. Hyperalgesia, allodynia, and spontaneous pain were assessed to evaluate nociception. These three signs were detected as early as 2 days after sciatic nerve constriction and lasted for over 14 days after CCI. Rats were treated with different doses of mS100A9p by intraplantar, oral, or intrathecal routes on day 14 after CCI, and nociception was evaluated 1 h later. These three routes of administration blocked hyperalgesia, allodynia and spontaneous pain. the duration of the effect of mS100A9p depends on the route used and phenomenon analyzed. Moreover, intraplantar injection of mS100A9p in the contralateral paw inhibited the hyperalgesia on day 14 days after CCI the results obtained herein demonstrate the antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain, suggesting a potential therapeutic use for it in persistent pain syndromes, assuming that tolerance does not develop to mS100A9p. (C) 2008 Elsevier Inc. All rights reserved.
Keywords Neuropathic pain
S100A9
Antinociception
Sciatic nerve
Chronic constriction injury
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundacao Butantan
Date 2008-10-01
Published in Peptides. New York: Elsevier B.V., v. 29, n. 10, p. 1806-1814, 2008.
ISSN 0196-9781 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1806-1814
Origin http://dx.doi.org/10.1016/j.peptides.2008.05.023
Access rights Closed access
Type Article
Web of Science ID WOS:000260284100022
URI http://repositorio.unifesp.br/handle/11600/30946

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account