Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function

Show simple item record

dc.contributor.author Fernandes, Fernanda B. [UNIFESP]
dc.contributor.author Plavnik, Frida L. [UNIFESP]
dc.contributor.author Teixeira, Andressa M. S. [UNIFESP]
dc.contributor.author Christofalo, Dejaldo M. J. [UNIFESP]
dc.contributor.author Ajzen, Sergio A. [UNIFESP]
dc.contributor.author Higa, Elisa M. S. [UNIFESP]
dc.contributor.author Ronchi, Fernanda A. [UNIFESP]
dc.contributor.author Sesso, Ricardo C. C. [UNIFESP]
dc.contributor.author Casarini, Dulce E. [UNIFESP]
dc.date.accessioned 2016-01-24T13:51:30Z
dc.date.available 2016-01-24T13:51:30Z
dc.date.issued 2008-07-01
dc.identifier http://dx.doi.org/10.2119/2007-00112.Fernandes
dc.identifier.citation Molecular Medicine. Manhasset: Feinstein Inst Med Res, v. 14, n. 7-8, p. 429-435, 2008.
dc.identifier.issn 1076-1551
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30750
dc.description.abstract The aim of this study was to investigate the association between urinary 90 kDa N-domain Angiotensin I-converting enzyme (ACE) form with C-reactive protein (CRP) and homocysteine plasma levels (Hcy), urinary nitric oxide (NOu), and endothelial function (EF) in normotensive subjects. Forty healthy subjects were evaluated through brachial Doppler US to test the response to reactive hyperemia and a panel of blood tests to determine CRP and Hcy levels, NOu, and urinary ACE. They were divided into groups according to the presence (ACE90+) or absence (ACE90-) of the 90 kDa ACE, the presence (FH+) or absence (FH-) of family history of hypertension, and the presence or absence of these two variables FH+/ACE90+ and FH-/ACE90-. We found an impaired endothelial dilatation in subjects who presented the 90 kDa N-domain ACE as follows: 11.4% +/- 5.3% in ACE90+ compared with 17.6% +/- 7.1% in ACE90- group and 12.4% +/- 5.6% in FH+/ACE90+ compared with 17.7% +/- 6.2% in FH-/ACE90- group, P < 0.05. Hcy and CRP levels were statistically significantly lower in FH+/ACE90+ than in FH-/ACE90- group, as follows: 10.0 +/- 2.3 mu M compared with 12.7 +/- 1.5 mu M, and 1.3 +/- 1.8 mg/L compared with 3.6 +/- 2.0 mg/L, respectively. A correlation between flow-mediated dilatation (FMD) and CRP, Hcy, and NOu levels was not found. Our study suggests a reduction in the basal NO production confirmed by NOu analysis in subjects with the 90 kDa N-domain ACE isoform alone or associated with a family history of hypertension, Our data suggest that the presence of the 90 kDa N-domain ACE itself may have a negative impact on flow-mediated dilatation stimulated by reactive hyperemia. en
dc.format.extent 429-435
dc.language.iso eng
dc.publisher Feinstein Inst Med Res
dc.relation.ispartof Molecular Medicine
dc.rights Acesso aberto
dc.title Association of urinary N-domain Angiotensin I-converting enzyme with plasma inflammatory markers and endothelial function en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Image Diagnost, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Oswaldo Ramos Fdn, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Emergency Div, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Image Diagnost, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Oswaldo Ramos Fdn, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Emergency Div, São Paulo, Brazil
dc.identifier.doi 10.2119/2007-00112.Fernandes
dc.description.source Web of Science
dc.identifier.wos WOS:000257727000009



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account