Hormonal alteration in obese adolescents with eating disorder: Effects of multidisciplinary therapy

Hormonal alteration in obese adolescents with eating disorder: Effects of multidisciplinary therapy

Author Carnier, June Autor UNIFESP Google Scholar
Lofrano, Mara Cristina Autor UNIFESP Google Scholar
Prado, Wagner Luiz do Autor UNIFESP Google Scholar
Caranti, Danielle Arisa Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background/Aims: Ghrelin and leptin play important roles in the physiopathology of eating disorders, starting generally in infancy and adolescence. the aim of this study was to evaluate the effects of multidisciplinary short-term therapy on ghrelin and leptin concentrations, bulimia nervosa symptoms, binge eating disorder symptoms, body composition, and visceral and subcutaneous fat in obese adolescents. Methods: Twenty obese adolescents with simple obesity (BMI > 95th percentile, 36.93 +/- 4.14, CDC) were submitted to multidisciplinary ( nutrition, psychology, exercise and clinical) therapy. Plasma ghrelin and leptin concentrations were measured by radioimmunoassay. Bulimic and binge eating behaviors were measured by the Bulimic Investigation Test Edinburgh and the Binge Eating Scale, respectively. Visceral and subcutaneous fat were measured by ultrasonography and body composition by plethysmography. Results: Significant reductions were observed in body weight (101.04 +/- 11.18 to 94.79 +/- 10.94 kg), BMI (36.93 +/- 4.14 to 34.27 +/- 4.78), fat% (41.96 +/- 6.28 to 39.14 +/- 7.62%), visceral fat (4.34 +/- 1.53 to 3.41 +/- 1.12 cm), leptin concentration (20.12 +/- 6.47 to 16.68 +/- 8.08 ng/ml), prevalence of bulimia nervosa (100 to 67%) and binge eating disorder symptoms (40 to 17%). Conclusion: Short-term multidisciplinary therapy was effective in improving body composition, visceral fat, leptinemia and eating disorders in obese adolescents. Copyright (C) 2008 S. Karger AG, Basel.
Keywords Leptin
Ghrelin
Binge eating disorder
Bulimia nervosa
Body composition
Language English
Date 2008-01-01
Published in Hormone Research. Basel: Karger, v. 70, n. 2, p. 79-84, 2008.
ISSN 0301-0163 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 79-84
Origin https://dx.doi.org/10.1159/000139148
Access rights Closed access
Type Article
Web of Science ID WOS:000257518300003
URI https://repositorio.unifesp.br/handle/11600/30356

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