Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas

Show simple item record

dc.contributor.author Ierardi, D. F.
dc.contributor.author Fernandes, M. J. S.
dc.contributor.author Silva, I. R.
dc.contributor.author Thomazini-Gouveia, J.
dc.contributor.author Silva, Nasjla Saba
dc.contributor.author Dastoli, Patricia
dc.contributor.author Toledo, Silvia Regina Caminada de [UNIFESP]
dc.contributor.author Cavalheiro, Sergio
dc.date.accessioned 2016-01-24T13:49:02Z
dc.date.available 2016-01-24T13:49:02Z
dc.date.issued 2007-09-01
dc.identifier http://dx.doi.org/10.1007/s00381-007-0409-3
dc.identifier.citation Childs Nervous System. New York: Springer, v. 23, n. 9, p. 1041-1046, 2007.
dc.identifier.issn 0256-7040
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29998
dc.description.abstract Objectives the aim of this study was to verify whether intracystic injections of alpha-Interferon (IFN-alpha) in cystic craniopharyngiomas were able to reduce the tumor by activating the Fas apoptotic pathway.Materials and methods Twenty-one patients with cystic craniopharyngiomas treated at the Pediatric Oncology Institute (IOP/GRAACC) of Federal University of São Paulo were submitted to intracystic chemotherapy with IFN-alpha. the tumor sizes of all patients were monitored and the apoptotic factor soluble FasL (sFasL) concentration was determined by ELISA (enzyme-linked immunosorbent assay) in tumor fluid samples from eight patients.Results There was a complete reduction in 11 patients, a partial response in seven, and a minor response in three patients. the concentration of sFasL was increased in all the eight patients examined concomitantly with the tumor size reduction.Conclusions Our data demonstrated that the IFN-a was able to induce Fas-mediated apoptosis together with a reduction in the tumor size; such an observation may suggest the importance to investigate still unexplored mechanisms to be exploited in craniopharyngioma therapy. en
dc.format.extent 1041-1046
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Childs Nervous System
dc.rights Acesso restrito
dc.subject cystic craniopharyngioma en
dc.subject alpha interferon apoptosis en
dc.subject Fas/FasL pathway en
dc.subject intratumoral chemotherapy en
dc.subject cell death pathways en
dc.subject Ommaya reservoir en
dc.title Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Pediat Oncol Inst, Dept Neurol & Neurosurg, BR-04023062 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Epilepsy Neurobiol Lab, Dept Neurol & Neurosurg, BR-04039032 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Pediat Oncol Inst, Dept Pediat, BR-04023062 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Pediat Oncol Inst, Dept Genet, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Pediat Oncol Inst, Dept Neurol & Neurosurg, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Epilepsy Neurobiol Lab, Dept Neurol & Neurosurg, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Pediat Oncol Inst, Dept Pediat, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Pediat Oncol Inst, Dept Genet, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1007/s00381-007-0409-3
dc.description.source Web of Science
dc.identifier.wos WOS:000249017700014



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account