Endurance training restores peritoneal macrophage function in post-MI congestive heart failure rats

Endurance training restores peritoneal macrophage function in post-MI congestive heart failure rats

Author Batista, M. L. Google Scholar
Santos, R. V. T. Autor UNIFESP Google Scholar
Oliveira, E. M. Google Scholar
Seelaender, M. C. L. Google Scholar
Rosa, L. F. B. P. Costa Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Mogi das Cruzes
Abstract Congestive heart failure (CHF) induces a state of immune activation, and peritoneal macrophages (M Phi s) may play an important role in the development and progression of one such condition. Moderate endurance training modulates peritoneal M Phi function. We evaluated the effect of endurance training on different stages of the phagocytic process and in the production of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) after LPS stimulation. Either ligation of the left coronary artery or Sham operations were performed in adult Wistar rats. After 4 wk, control (Sham operated) and MI (ligation of the left coronary artery) animals were randomly assigned to either a sedentary (Sham-operated sedentary, n = 7 and MI sedentary, n = 10) or a trained group (Sham-operated trained, n = 8 and MI trained, n = 8). Trained rats ran on a treadmill (0% grade at 13-20 m/min) for 60 min/day, 5 days/wk, for 8-10 wk, whereas sedentary rats had only limited activity. Training increased maximal oxygen uptake normalized for body weight (ml . kg(-1). min(-1)), as well as skeletal muscle citrate synthase maximal activity, when compared with sedentary groups. the resident and total cell number, the chemotaxis index, and the production of TNF-alpha stimulated by LPS were significantly higher in the MI sedentary group when compared with the Sham sedentary group. Moderate endurance training reversed these alterations promoted by post-MI. These results demonstrate that moderate intensity exercise training modulates peritoneal M Phi function and induces beneficial metabolic effects in rats with post-MI CHF.
Keywords pro-inflammatory cytokines
chemotaxis index
phagocytic capacity
exercise adaptation
myocardial infarction
Language English
Date 2007-05-01
Published in Journal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 102, n. 5, p. 2033-2039, 2007.
ISSN 8750-7587 (Sherpa/Romeo, impact factor)
Publisher Amer Physiological Soc
Extent 2033-2039
Origin http://dx.doi.org/10.1152/japplphysiol.00871.2006
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000248410600041
URI http://repositorio.unifesp.br/handle/11600/29682

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