Resting energy expenditure and its determinants in hemodialysis patients

Resting energy expenditure and its determinants in hemodialysis patients

Author Kamimura, Maria Ayako Autor UNIFESP Google Scholar
Draibe, Sergio Antonio Autor UNIFESP Google Scholar
Avesani, Carla Maria Autor UNIFESP Google Scholar
Canziani, Maria Eugênia Fernandes Autor UNIFESP Google Scholar
Colugnati, Fernando Antonio Basile Autor UNIFESP Google Scholar
Cuppari, Lilian Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: Chronic kidney disease is associated with several metabolic disturbances that can affect energy metabolism. As resting energy expenditure (REE) is scarcely investigated in patients on hemodialysis (HD) therapy, we aimed to evaluate the REE and its determinants in HD patients.Design: Cross-sectional study.Setting: Dialysis Unit of the Nephrology Division, Federal University of São Paulo, Brazil.Subjects: the study included 55 patients ( 28 male, 41.4 +/- 12.6 years old) undergoing HD therapy thrice weekly for at least 2 months, and 55 healthy individuals pair matched for age and gender. Subjects underwent fasting blood tests, as well as nutritional assessment, and the REE was assessed by indirect calorimetry.Results: REE of HD patients was similar to that of pair-matched controls (1379 +/- 7272 and 1440 +/- 7259 kcal/day, respectively), even when adjusted for fat-free mass (P = 0.24). REE of HD patients correlated positively with fat-free mass (r = 0.74; P < 0.001) and body mass index (r = 0.37; P < 0.01), and negatively with dialysis adequacy (r = -0.46; P < 0.001). No significant univariate correlation was found between REE and age, dialysis vintage, serum creatinine, urea, albumin, bicarbonate, parathyroid hormone (PTH) or high-sensitivity C-reactive protein (CRP). in the multiple linear regression analysis, using REE as dependent variable, the final model showed that besides the well-recognized determinants of REE such as fat-free mass and age, PTH and CRP were the independent determinants of REE in HD patients (R-2 = 0.64).Conclusions: in this study, the REE of HD patients was similar to that of healthy individuals, even with the positive effect of secondary hyperparathyroidism and inflammation on REE of these patients.
Keywords hemodialysis
energy metabolism
Language English
Date 2007-03-01
Published in European Journal of Clinical Nutrition. London: Nature Publishing Group, v. 61, n. 3, p. 362-367, 2007.
ISSN 0954-3007 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent 362-367
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000244570600009

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account