The developmental nephrome: systems biology in the developing kidney

Show simple item record

dc.contributor.author Monte, Julio C.
dc.contributor.author Sakurai, Hiroyuki
dc.contributor.author Bush, Kevin T.
dc.contributor.author Nigam, Sanjay K.
dc.date.accessioned 2016-01-24T12:41:46Z
dc.date.available 2016-01-24T12:41:46Z
dc.date.issued 2007-01-01
dc.identifier http://dx.doi.org/10.1097/MNH.0b013e3280118a5a
dc.identifier.citation Current Opinion in Nephrology and Hypertension. Philadelphia: Lippincott Williams & Wilkins, v. 16, n. 1, p. 3-9, 2007.
dc.identifier.issn 1062-4821
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29421
dc.description.abstract Purpose of reviewA set of important genes and signaling pathways involved in kidney development is emerging from analyses of mutant mice, in-vitro models, and global gene expression patterns. Conversion of data into dynamic models or networks through the synthesis of information at multiple levels is crucial for a better understanding of kidney development.Recent findingsGenetic and in-vitro evidence is beginning to provide a limited sense of the network topology in stages, of kidney development. Intriguing data from other fields suggest how, with the aid of large-scale gene expression studies, these stages might be represented as dynamic attractor states. It is also suggested how branching morphogenesis of the epithelial ureteric bud may be sustained by an autocatalytic set of proteins whose interactions lead to repeated rounds of tip and stalk generation. Accumulating data in lower organisms suggest network topologies may be quite flexible, and the implications of these results for varieties of tubulogenesis and renal regeneration after acute injury are discussed.SummaryCurrently it may be feasible to build tentative dynamic multistage models of nephrogenesis that facilitate experimental thinking. As data accumulate, it may become possible to test their predictive value. en
dc.format.extent 3-9
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Current Opinion in Nephrology and Hypertension
dc.rights Acesso restrito
dc.subject acute renal failure en
dc.subject attractor en
dc.subject autocatalytic en
dc.subject branching morphogenesis en
dc.subject nonlinear dynamics en
dc.subject scale-free network en
dc.title The developmental nephrome: systems biology in the developing kidney en
dc.type Resenha
dc.contributor.institution Univ Calif San Diego
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliation Univ Calif San Diego, Sch Med, Dept Pediat, La Jolla, CA 92093 USA
dc.description.affiliation Univ Calif San Diego, Sch Med, Dept Cellular Mol Med, La Jolla, CA 92093 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Div Nephrol, São Paulo, Brazil
dc.identifier.doi 10.1097/MNH.0b013e3280118a5a
dc.description.source Web of Science
dc.identifier.wos WOS:000243149100002



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account