Effect of microcystin on leukocyte viability and function

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dc.contributor.author Goncalves, EAP
dc.contributor.author Dalboni, Maria Aparecida [UNIFESP]
dc.contributor.author Peres, A. T.
dc.contributor.author Manfredi, A. P.
dc.contributor.author Manfredi, SR
dc.contributor.author Azevedo, S. M.
dc.contributor.author Magalhaes, V. F.
dc.contributor.author Draibe, S.
dc.contributor.author Canziani, MEF
dc.contributor.author Cendoroglo, M.
dc.date.accessioned 2016-01-24T12:41:14Z
dc.date.available 2016-01-24T12:41:14Z
dc.date.issued 2006-06-01
dc.identifier http://dx.doi.org/10.1016/j.toxicon.2006.02.008
dc.identifier.citation Toxicon. Oxford: Pergamon-Elsevier B.V., v. 47, n. 7, p. 774-779, 2006.
dc.identifier.issn 0041-0101
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28957
dc.description.abstract Microcystin (MC) has been found in several areas of the world. in addition to its hepatotoxicity, microcystin may have an immunomodulatory effect.Considering that patients receiving hemodialysis may be chronically exposed to variable concentrations of MC, and that they present important changes in this immune response, we have assessed the effect of MC on the function of leukocytes.Polymorphonuclear leukocytes isolated from health), volunteers (HV) and patients receiving hemodialysis (HD) were incubated with microcystin (10 mu g/L) for 24 h and evaluated for reactive oxygen species production (ROS), phagocytosis and apoptosis. Monocytes incubated with and without LPS (100 ng/mL) and microcystin for 24 h were assessed for TNF alpha and IL10 production.Leukocytes of HV presented an increase in apoptosis rates and leukocytes from HD exhibited a lower production of oxygen-reactive species, both spontaneously and after stimulus with S. aureus, when compared with leukocytes incubated without toxin.Monocytes presented an increase in cytokine production after stimulation by LPS in both groups, but there was no difference between the groups with and without MC that were incubated with or without LPS.Low concentrations of microcystin can induce mild changes in leukocyte function of HV and HDP, particularly in the ability to produce ROS. (c) 2006 Elsevier B.V. All rights reserved. en
dc.format.extent 774-779
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Toxicon
dc.rights Acesso restrito
dc.subject apoptosis en
dc.subject reactive oxygen species en
dc.subject phagocytosis en
dc.subject microcystin en
dc.subject polymorphonuclear leukocytes en
dc.subject cytokine en
dc.title Effect of microcystin on leukocyte viability and function en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.description.affiliation Fed Univ São Paulo, Dept Med, Div Nephrol, São Paulo, SP, Brazil
dc.description.affiliation Fed Univ Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Rio de Janeiro, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo, Dept Med, Div Nephrol, São Paulo, SP, Brazil
dc.identifier.doi 10.1016/j.toxicon.2006.02.008
dc.description.source Web of Science
dc.identifier.wos WOS:000238466300008


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