Expression of EpCAM in uveal melanoma

Expression of EpCAM in uveal melanoma

Author Odashiro, Danilo Nakao Autor UNIFESP Google Scholar
Odashiro, Alexandre Nakao Autor UNIFESP Google Scholar
Pereira, Patricia da Rocha Autor UNIFESP Google Scholar
Godeiro, Katyanne Autor UNIFESP Google Scholar
Antecka, Emilia Google Scholar
Di Cesare, Sebastian Google Scholar
Burnier Júnior, Miguel Noel Nascente Autor UNIFESP Google Scholar
Institution McGill Univ
Universidade Federal de São Paulo (UNIFESP)
LAC Pathol & Cytopathol Lab
Universidade Estadual de Campinas (UNICAMP)
Abstract Background: Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults, and nearly 40% of UM will develop metastasis that will ultimately lead to death. the Epithelial Cell Adhesion Molecule (EpCAM) is a type I transmembrane glycoprotein expressed by carcinomas of head and neck, ovary, colon, breast, kidney and lung. Recently, antibodies against EpCAM such as Edrecolomab and Catumaxomab were developed, and clinical trials with these antibodies have been used in several types of neoplasia. We studied the expression of EpCAM in UM.Methods: 25 enucleated formalin-fixed, paraffin-embedded UM specimens were immunostained for EpCAM. Histopathological analysis of the specimens with regards to prognostic factors such as cell type, largest (linear) tumor dimension, number of mitotic figures, scleral invasion and tumor infiltrating lymphocytes were done.Results: None of them was positive for this EpCAM.Conclusion: in our report, UM did not express EpCAM. Therefore, it is not a helpful immunohistochemical marker to predict the behavior of UM. Further studies are needed to verify if EpCAM could also be related with prognosis and treatment of UM.
Language English
Date 2006-01-01
Published in Cancer Cell International. London: Biomed Central Ltd, v. 6, 5 p., 2006.
ISSN 1475-2867 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 5
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000208405000026

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