The C-terminus of murine S100A9 inhibits spreading and phagocytic activity of adherent peritoneal cells

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dc.contributor.author Pagano, R. L.
dc.contributor.author Sampaio, S. C.
dc.contributor.author Juliano, L.
dc.contributor.author Juliano, M. A.
dc.contributor.author Giorgi, R.
dc.date.accessioned 2016-01-24T12:37:49Z
dc.date.available 2016-01-24T12:37:49Z
dc.date.issued 2005-05-01
dc.identifier http://dx.doi.org/10.1007/s00011-005-1344-y
dc.identifier.citation Inflammation Research. Basel: Birkhauser Verlag Ag, v. 54, n. 5, p. 204-210, 2005.
dc.identifier.issn 1023-3830
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28273
dc.description.abstract Objective and design: in the present study, the effect of a synthetic peptide (H-92-G(102)) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on adherent peritoneal cell function.Materials and methods: for in vitro assays, peritoneal cells were obtained from the abdominal cavity of mice and incubated, with the different concentrations of mS100A9p, for 1 h, and then their spreading and phagocytosis activities were evaluated. for ex-vivo assays, cells obtained from animals treated for 1 h with the peptide were submitted to the mannose-receptor phagocytosis assay. Shorter homologue peptides to the C-terminus of mS100A9p were also evaluated on in vitro phagocytosis assays of Candida albicans particles.Results: mS100A9p reduced both the spreading index and phagocytic activity, in vitro and ex-vivo, independent of the receptor evaluated. the homologue peptide corresponding to the H-92-E-97 region of mS100A9p, the zinc-binding motif, was responsible for such an effect.Conclusion: These results suggest a modulator effect of the C-terminus of S100A9 protein on the function of adherent peritoneal cells. en
dc.format.extent 204-210
dc.language.iso eng
dc.publisher Birkhauser Verlag Ag
dc.relation.ispartof Inflammation Research
dc.rights Acesso restrito
dc.subject S100A9 en
dc.subject adherent peritoneal cells en
dc.subject spreading en
dc.subject phagocytosis en
dc.subject zinc en
dc.title The C-terminus of murine S100A9 inhibits spreading and phagocytic activity of adherent peritoneal cells en
dc.type Artigo
dc.contributor.institution Butantan Inst
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Butantan Inst, Lab Pathophysiol, BR-05503900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Inst Pharm, Dept Biophys, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Inst Pharm, Dept Biophys, BR-04044020 São Paulo, Brazil
dc.identifier.doi 10.1007/s00011-005-1344-y
dc.description.source Web of Science
dc.identifier.wos WOS:000229641000003



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