Risk factors for asthma and atopy

Risk factors for asthma and atopy

Author Arruda, L. K. Google Scholar
Sole, D. Google Scholar
Baena-Cagnani, Carlos E. Google Scholar
Naspitz, C. K. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Catholic Univ Cordoba
Abstract Purpose of review the aim of this article is to provide information on risk factors associated with the development of atopy and asthma in childhood.Recent findings Several gene polymorphisms have been associated with susceptibility to asthma and allergy; complex gene-environmental interactions, however, appear to play a key role in the development of the disease. Early life sensitization to aeroallergens, presence of atopic dermatitis or allergic rhinitis, maternal smoking during pregnancy and children's environmental exposure to tobacco smoke, lower respiratory tract infections with respiratory syncytial virus and potentially with other viruses including rhinovirus and metapneumovirus, exposure to air pollutants, several perinatal factors other than maternal smoking, are among factors associated with an increased risk for development of chronic asthma.Summary the prevalence of asthma and allergic diseases is increasing progressively. Those who are involved in the care of young children should be prepared to recognize risk factors for development of these diseases and to appreciate the role of gene-environment interactions. Preventive measures established at an early age may modify the natural history of asthma and other allergic diseases.
Keywords allergen sensitization
asthma
gene-environment interactions
respiratory viral infections
risk factors for asthma
Language English
Date 2005-04-01
Published in Current Opinion in Allergy and Clinical Immunology. Philadelphia: Lippincott Williams & Wilkins, v. 5, n. 2, p. 153-159, 2005.
ISSN 1528-4050 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 153-159
Origin http://dx.doi.org/10.1097/01.all.0000162308.89857.6c
Access rights Closed access
Type Review
Web of Science ID WOS:000232293000008
URI http://repositorio.unifesp.br/handle/11600/28235

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