Noradrenergic system interacts with genital reflexes induced by cocaine in paradoxical sleep-deprived male rats

Noradrenergic system interacts with genital reflexes induced by cocaine in paradoxical sleep-deprived male rats

Author Andersen, M. L. Google Scholar
Antunes, I. B. Google Scholar
Tufik, S. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Different doses of alpha-1, alpha-2, beta-1, and beta-2 adrenoceptor agonists or antagonists were administered to paradoxical sleep-deprived (PSD) rats prior to cocaine administration. Metboxamine reduced the percentage of rats displaying erection, whereas prazosin did not. Yohimbine significantly decreased this percentage. for beta-1 adrenoceptor drugs, both compounds reduced the percentage of rats displaying erection at the highest dose; beta-2 adrenoceptor drugs had no effect. Except for clonidine, all drugs significantly reduced the frequency of erection. Ejaculation was significantly decreased following yohimbine and beta-1 drugs, whereas it was completely abolished by prazosin. the results showed that noradrenergic drugs inhibited genital reflexes in PSD rats, with distinct responses in relation to their respective action over the adrenoceptor.
Keywords sleep deprivation
genital reflexes
cocaine
noradrenergic system
alpha and beta receptors
Language English
Date 2005-04-01
Published in Behavioral Neuroscience. Washington: Amer Psychological Assoc, v. 119, n. 2, p. 473-482, 2005.
ISSN 0735-7044 (Sherpa/Romeo, impact factor)
Publisher Amer Psychological Assoc
Extent 473-482
Origin http://dx.doi.org/10.1037/0735-7044.119.2.473
Access rights Closed access
Type Article
Web of Science ID WOS:000228428700011
URI http://repositorio.unifesp.br/handle/11600/28228

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