Serotonin involvement in the electroacupuncture- and moxibustion-induced gastric emptying in rats

Serotonin involvement in the electroacupuncture- and moxibustion-induced gastric emptying in rats

Author Sugai, GCM Google Scholar
Freire, A. D. Google Scholar
Tabosa, A. Google Scholar
Yamamura, Y. Google Scholar
Tufik, S. Google Scholar
Mello, LEAM Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: Electroacupuncture (EA) as well as moxibustion stimulation has been reported to produce an excitatory effect on the gastrointestinal motility of the rat. Serotonergic neurons of the mioenteric and submucous plexus are major participants in the gastrointestinal physiology. Here, we compared the outcomes of the stimulation of a specific set of acupoints with either acupuncture or moxibustion on the gastrointestinal motility and the role of serotonin (5-HT) in this effect.Methods: To analyze the role of 5-HT on the gastrointestinal motility of the rat, we studied the flow of 25 glass beads administered to the stomach, after treatment of the animals with a serotonin inhibitor (para-chlorophenylalanine [pCPA]). Acupuncture stimulation was performed on acupoints St-36 (Zusanli) and Sp-6 (Sanyinjiao), with electrical stimulation, or on acupoints Ren-10 (Xiawan), Ren-12 (Zhongwan) and St-25 (Tianshu), with moxibustion. Animals subjected to sham stimulation were used as controls in addition to naive, unstimulated animals.Results: Stimulation of the hind limb (St-36 and Sp-6) and abdominal (Ren-10, Ren-12, St-25) acupoints resulted in effective gastric emptying, as compared with sham-stimulated animals. Pretreatment of animals with pCPA abolished either the response provided by acupuncture stimulation in animal groups subjected to hind limb acupoints or the response provided by moxibustion stimulation in abdominal acupoints.Conclusion: Our data suggest that moxibustion in the abdominal points and EA in the hind limb require an intact serotonergic pathway. in addition, we suggest that this involvement of serotonin is a general feature of the mediated effects of acupuncture on gastric emptying of the rat. (C) 2004 Elsevier Inc. All rights reserved.
Keywords electroacupuncture
gastric emptying
Language English
Date 2004-10-15
Published in Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 82, n. 5, p. 855-861, 2004.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 855-861
Access rights Closed access
Type Article
Web of Science ID WOS:000224440900011

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