Feeding induced by increasing doses of neuropeptide Y: Dual effect on hypothalamic serotonin release in normal rats

Feeding induced by increasing doses of neuropeptide Y: Dual effect on hypothalamic serotonin release in normal rats

Author Mori, RCT Google Scholar
Telles, M. M. Google Scholar
Guimaraes, R. B. Google Scholar
Nova, N. F. Google Scholar
Juliano, Y. Google Scholar
Nascimento, CMO Google Scholar
Ribeiro, E. B. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Endogenous neuropeptide Y (NPY) levels increase during fasting and before dark onset in rats. the feeding that follows these states elicits the release of serotonin in the lateral hypothalamus (LH), as part of the physiological mechanisms controlling satiety. With the hypothesis that exogenous NPY-induced feeding should also stimulate serotonin, we measured its release in the LH of non-fasted rats, which received a single intracerebroventricular injection of either 1.0, 2.0, or 5.0 mug of NPY. After 1.0 mug, the cumulative 2-h intake was of 13 g and serotonin release significantly increased (54% peak). These feeding and serotonergic responses were highly similar to the ones we observed in a previous study, in which feeding followed an overnight fast. Thus, the 1.0 mug NPY dose stimulated intake while preserving the normal serotonergic activation. Contrarily, as the NPY dose was increased to either 2.0 or 5.0 mug, the cumulative 2-h intakes were of 18 g, but the serotonergic stimulation was absent. It is suggested that this dual NPY effect relies on a finely tuned control mechanism, reflecting the existence of a narrow range of NPY levels within which the serotonergic stimulation resembles those seen in physiological states.
Keywords brain microdialysis
food intake
neuropeptide
Y
lateral hypothalamus
serotonin
Language English
Date 2004-08-01
Published in Nutritional Neuroscience. Abingdon: Taylor & Francis Ltd, v. 7, n. 4, p. 235-239, 2004.
ISSN 1028-415X (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 235-239
Origin http://dx.doi.org/10.1080/10284150400012794
Access rights Closed access
Type Article
Web of Science ID WOS:000226385100006
URI http://repositorio.unifesp.br/handle/11600/27862

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