C-13-urea breath test to diagnose Helicobacter pylori infection in children aged up to 6 years

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dc.contributor.author Machado, R. S.
dc.contributor.author Patricio, FRD
dc.contributor.author Kawakami, E.
dc.date.accessioned 2016-01-24T12:34:13Z
dc.date.available 2016-01-24T12:34:13Z
dc.date.issued 2004-01-01
dc.identifier http://dx.doi.org/10.1111/j.1083-4389.2004.00196.x
dc.identifier.citation Helicobacter. Malden: Wiley-Blackwell, v. 9, n. 1, p. 39-45, 2004.
dc.identifier.issn 1083-4389
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27565
dc.description.abstract Background. C-13-urea breath test (C-13-UBT) is an accurate noninvasive tool for diagnosis of Helicobacter pylori infection. It is considered the best method for epidemiological studies, but there are few studies to evaluate the C-13-UBT in infants and toddlers.Aim. To evaluate the C-13-UBT performed with infrared spectroscopy in children aged up to 6 years.Patients. Sixty-eight patients (6 months. to 5 years 11 months.) were evaluated prospectively and consecutively.Methods. Helicobacter pylori infection was detected by positive culture, or rapid urease test and histological examination, both positive. C-13-UBT was performed with 50 mg of C-13-urea diluted in 100 ml of commercial orange juice. Two expired air samples were collected: before and 30 minutes after tracer ingestion. Cutoff of delta over baseline (DOB) was 4.0parts per thousand and urea hydrolysis rate 10 mug/minute. Results. Fifteen of 68 (22.1%) patients were H. pylori infected. Sensitivity was 93.3% (95% Cl; 86.8%-99.7%) and specificity was 96.2% (95% CI; 93.6%-98.8%), and these values were equal for DOB and urea hydrolysis rate. Negative DOB values in noninfected patients ranged from -1.5parts per thousand to 2.6parts per thousand and positive DOB values ranged from 10.8parts per thousand. to 105.5parts per thousand. There was no relationship between DOB values and age.Conclusion. C-13-UBT performed with infrared spectroscopy proved to be a reliable and accurate noninvasive diagnostic tool for H. pylori infection detection in children aged up to 6 years. Results far from cutoff value can clearly distinguish positive from negative C-13-UBT results in children up to 6 years old. en
dc.format.extent 39-45
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Helicobacter
dc.rights Acesso restrito
dc.title C-13-urea breath test to diagnose Helicobacter pylori infection in children aged up to 6 years en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Pediat, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Pathol, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1083-4389.2004.00196.x
dc.description.source Web of Science
dc.identifier.wos WOS:000189210000005



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