Haplotypes of alpha-globin gene regulatory element in two Brazilian native populations

Haplotypes of alpha-globin gene regulatory element in two Brazilian native populations

Author Ribeiro, D. M. Google Scholar
Figueiredo, M. S. Google Scholar
Costa, F. F. Google Scholar
Sonati, M. F. Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Abstract The alpha-major regulatory element (alpha-MRE), located 40 Kb far upstream of the alpha-globin gene cluster on chromosome 16, is involved in the regulation of human at-globin genes expression. the activity of this element is restricted to a 350-bp fragment in which several nuclear protein binding sites have been identified. This element is genetically polymorphic and different haplotypes, named A-F, have been determined in seven populations of Europe, Africa, Asia, and Oceania. We describe here the alpha-MRE haplotypes found in native Indians from two non-miscegenated tribes of the north region of Brazil, in Amazonia, the Parakana and the Xikrin. the A haplotype was predominant in both (70% and 87%, respectively), followed by the B haplotype (30% and 13%, respectively). the haplotype frequency distribution among the Parakana was similar to that reported for Indonesians and Southeast Asian populations, while the distribution among the Xikrin showed higher similarity to that observed in Indonesians. These results corroborate the existence of genetic affinities between Brazilian Indians and Southeast Asian and Oceanic populations. This was the first investigative work on the alpha-MRE polymorphism in South American native populations in general or Brazilian native populations in particular. (C) 2003 Wiley-Liss, Inc.
Keywords alpha-MRE haplotypes
genetic polymorphisms
Brazilian population
South American Indians
Language English
Date 2003-05-01
Published in American Journal of Physical Anthropology. New York: Wiley-liss, v. 121, n. 1, p. 58-62, 2003.
ISSN 0002-9483 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 58-62
Origin http://dx.doi.org/10.1002/ajpa.10193
Access rights Closed access
Type Article
Web of Science ID WOS:000182336300007
URI http://repositorio.unifesp.br/handle/11600/27224

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