Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes

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dc.contributor.author Ropert, C.
dc.contributor.author Ferreira, LRP
dc.contributor.author Campos, MAS
dc.contributor.author Procopio, D. O.
dc.contributor.author Travassos, L. R.
dc.contributor.author Ferguson, MAJ
dc.contributor.author Reis, LFL
dc.contributor.author Teixeira, M. M.
dc.contributor.author Almeida, I. C.
dc.contributor.author Gazzinelli, R. T.
dc.date.accessioned 2016-01-24T12:33:26Z
dc.date.available 2016-01-24T12:33:26Z
dc.date.issued 2002-07-01
dc.identifier http://dx.doi.org/10.1016/S1286-4579(02)01609-X
dc.identifier.citation Microbes and Infection. Paris Cedex 15: Editions Scientifiques Medicales Elsevier, v. 4, n. 9, p. 1015-1025, 2002.
dc.identifier.issn 1286-4579
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26912
dc.description.abstract Activation of cells from the innate immune system has an important role in host resistance to early infection with the intracellular protozoan parasite, Trypanosoma cruzi. Here we review the studies that have identified and structurally characterized the glycosylphosphatidylinositol (GPI) anchors, as parasite molecules responsible for the activation of cells from the macrophage lineage. We also cover the studies that have identified the receptor, signaling pathways as well as the array of genes expressed in macrophages that are activated by these glycoconjugates. We discuss the possible-implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved. en
dc.format.extent 1015-1025
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Microbes and Infection
dc.rights Acesso restrito
dc.subject Trypanosoma cruzi en
dc.subject GPI anchors en
dc.subject TLR-2 en
dc.subject macrophages en
dc.subject chemokines en
dc.title Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Fiocruz MS
dc.contributor.institution Universidade Federal de Minas Gerais (UFMG)
dc.contributor.institution Ludwig Inst Canc Res
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Dundee
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Fiocruz MS, CPqRR, Immunopathol Lab, BR-30190002 Belo Horizonte, MG, Brazil
dc.description.affiliation UFMG, ICB, Dept Biochem & Immunol, BR-31270901 Belo Horizonte, MG, Brazil
dc.description.affiliation Ludwig Inst Canc Res, BR-01509010 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Expt Oncol Unit, BR-04023062 São Paulo, Brazil
dc.description.affiliation Univ Dundee, Dept Biochem, Dundee DD1 5EH, Scotland
dc.description.affiliation Univ São Paulo, ICB, Dept Parasitol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Expt Oncol Unit, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1016/S1286-4579(02)01609-X
dc.description.source Web of Science
dc.identifier.wos WOS:000178156700017



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