Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes

Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes

Autor Ropert, C. Google Scholar
Ferreira, LRP Google Scholar
Campos, MAS Google Scholar
Procopio, D. O. Google Scholar
Travassos, L. R. Google Scholar
Ferguson, MAJ Google Scholar
Reis, LFL Google Scholar
Teixeira, M. M. Google Scholar
Almeida, I. C. Google Scholar
Gazzinelli, R. T. Google Scholar
Instituição Fiocruz MS
Universidade Federal de Minas Gerais (UFMG)
Ludwig Inst Canc Res
Universidade Federal de São Paulo (UNIFESP)
Univ Dundee
Universidade de São Paulo (USP)
Resumo Activation of cells from the innate immune system has an important role in host resistance to early infection with the intracellular protozoan parasite, Trypanosoma cruzi. Here we review the studies that have identified and structurally characterized the glycosylphosphatidylinositol (GPI) anchors, as parasite molecules responsible for the activation of cells from the macrophage lineage. We also cover the studies that have identified the receptor, signaling pathways as well as the array of genes expressed in macrophages that are activated by these glycoconjugates. We discuss the possible-implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
Palavra-chave Trypanosoma cruzi
GPI anchors
TLR-2
macrophages
chemokines
Idioma Inglês
Data de publicação 2002-07-01
Publicado em Microbes and Infection. Paris Cedex 15: Editions Scientifiques Medicales Elsevier, v. 4, n. 9, p. 1015-1025, 2002.
ISSN 1286-4579 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1015-1025
Fonte http://dx.doi.org/10.1016/S1286-4579(02)01609-X
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000178156700017
Endereço permanente http://repositorio.unifesp.br/handle/11600/26912

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