Evaluation of the anxiolytic-like effects of Cecropia glazioui Sneth in mice

Evaluation of the anxiolytic-like effects of Cecropia glazioui Sneth in mice

Author Rocha, F. F. Google Scholar
Lapa, A. J. Google Scholar
De Lima, TCM Google Scholar
Institution Universidade Federal de Santa Catarina (UFSC)
Universidade Federal de São Paulo (UNIFESP)
Abstract Cecropia glazioui Sneth has been used in most Latin American countries as an antihypertensive, cardiotonic, and antiasthmatic folk medicine. in the cardiovascular studies to define its antihypertensive action it was noteworthy that animals treated with the aqueous extract (AE) of C. glazioui were much calmer than control animals. That observation prompted the present study, aimed at an investigation of the effects of AE and of two semipurified fractions on mouse behavior as evaluated in the elevated plus-maze test (EPM). Male adult Swiss mice were treated with AE (0.25-1 g/kg po) acutely (1 h) or repeatedly (24, 7, and 1.5 h before the test). After repeated administration of AE, the frequency of entries in the open arms of EPM was increased threefold. A similar profile of action was observed after treatment with the butanolic fraction (Fbut) but not with the aqueous fraction (Faq). These findings suggest that the AE of C. glazioui promotes an anxiolytic-like effect in mice. the active principles responsible for this action are present in the less polar fraction of the extract, the main constituents of which are flavonoids and terpenes, among other compounds. (C) 2002 Elsevier Science Inc. All rights reserved.
Keywords anxiety
medicinal plant
validation
phytomedicine
plus-maze
Language English
Date 2002-01-01
Published in Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 71, n. 1-2, p. 183-190, 2002.
ISSN 0091-3057 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 183-190
Origin http://dx.doi.org/10.1016/S0091-3057(01)00695-5
Access rights Closed access
Type Article
Web of Science ID WOS:000173687300020
URI http://repositorio.unifesp.br/handle/11600/26697

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