Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy

Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy

Author Perosa, Sandra Regina Autor UNIFESP Google Scholar
Porcionatto, Marimélia Aparecida Autor UNIFESP Google Scholar
Cukiert, A. Google Scholar
Martins, João Roberto Maciel Autor UNIFESP Google Scholar
Amado, Débora Autor UNIFESP Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Leite, J. P. Google Scholar
Naffah-Mazzacoratti, Maria da Graca Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Brigadeiro
Universidade de São Paulo (USP)
Abstract Purpose: This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE).Methods: the GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA).Results: the hippocampus of TLE patients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF).Conclusions: These results suggest that these matrix components could be involved in the pathophysiology of TLE.
Keywords chondroitin sulfate
heparan sulfate
hyaluronic acid
temporal lobe epilepsy
Language English
Date 2002-01-01
Published in Epilepsia. Malden: Blackwell Publishing Inc, v. 43, p. 159-161, 2002.
ISSN 0013-9580 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing Inc
Extent 159-161
Origin http://dx.doi.org/10.1046/j.1528-1157.43.s.5.30.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000177445900029
URI http://repositorio.unifesp.br/handle/11600/26682

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