Gastro cystoplasty and chronic renal failure: An acid-base metabolism study

Gastro cystoplasty and chronic renal failure: An acid-base metabolism study

Author Freitas, L. G. de Google Scholar
Carnevale, J. Google Scholar
Leao, JQS Google Scholar
Schor, N. Google Scholar
Ortiz, V Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: To verify in an experimental model whether gastrocystoplasty may protect patients with chronic renal failure from acid loading associated acidosis a wedge-shaped portion of the middle stomach was used to improve bladder capacity in animals with chronic renal failure.Materials and Methods: An experimental model was used to study 112 adult female Wistar rats (EPM-1) weighing between 156 and 259 gm. the animals were randomly assigned to groups, including 41 controls, 24 undergoing five-sixths nephrectomy to create chronic renal failure, 26 undergoing gastrocystoplasty and 21 undergoing gastrocystoplasty and five-sixths nephrectomy to create renal failure. To provide an acid overload a 5% NH4Cl diet was administered to a subgroup of each group. Two months after surgery 24-hour urine was collected, and volume and pH were measured as well as the amount of bicarbonate, ammonium, titratable acidity and chloride. the animals were then exsanguinated through an abdominal aorta puncture. the blood was used for blood gas analysis and to measure sodium, potassium, chloride, ionized calcium and creatinine.Results: When undergoing an acid overload, the animals with gastrocystoplasty had no acidosis since acid radicals were eliminating in the urine as NH4Cl. When given the same acid overload, metabolic acidosis developed in the animals with gastrocystoplasty and chronic renal failure.Conclusions: Gastrocystoplasty protected healthy rats from acidosis when they were given an acid overload but failed to protect the rats with chronic renal failure under the same conditions.
Keywords kidney
urinary diversion
rats, Wistar
Language English
Date 2001-07-01
Published in Journal of Urology. Philadelphia: Lippincott Williams & Wilkins, v. 166, n. 1, p. 251-254, 2001.
ISSN 0022-5347 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 251-254
Access rights Closed access
Type Article
Web of Science ID WOS:000169268700082

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