Antibody response to the N and C-terminal regions of the Plasmodium vivax Merozoite Surface Protein 1 in individuals living in an area of exclusive transmission of P-vivax malaria in the north of Brazil

Antibody response to the N and C-terminal regions of the Plasmodium vivax Merozoite Surface Protein 1 in individuals living in an area of exclusive transmission of P-vivax malaria in the north of Brazil

Author Soares, I. S. Google Scholar
Oliveira, S. G. Google Scholar
Souza, J. M. Google Scholar
Rodrigues, M. M. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fed Univ Para
Inst Evandro Chagas
Abstract Recently, we found that a recombinant protein based on the 19 kDa C-terminal region of the Plasmodium vivax Merozoite Surface Protein 1 (PvMSP1(19)) was recognized by a large proportion of individuals naturally infected. the present study was designed to determine the prevalence of antibody to PvMSP1(19) in individuals from the village of Cotijuba, northern Brazil, where only P. vivax transmission occurs. Immuno-epidemiological studies on the prevalence of antibody to the C-terminus of PvMSP1 are of particular importance as this region of MSP1 is bring intensively studied as a prime candidate for development of a vaccine against malaria. We evaluated the antibody response to PvMSP1(19), and compared it to the N-terminal region of PvMSP1 and to blood stage antigens. the total frequencies of individuals with IgG to blood stages, PvMSP1(19) or the N-terminal region of PvMSP1 were 76.6, 42.3 and 29.8%, respectively. the frequency of responders to PvMSP1(19) did not increase with age. However, the frequency of responders to this recombinant protein was significantly higher (77.4%) in individuals with a recent (<6 months) history of malaria, when compared to subjects whose last malaria attack occurred more than 6 months before (43.9%), or to individuals without a past history of symptomatic malaria (6.25%). These results confirm earlier studies by demonstrating that the PvMSPI(19) is highly immunogenic in individuals recently exposed to P. vivax malaria. (C) 1999 Published by Elsevier Science B.V. All rights reserved.
Keywords P-vivax
malaria
merozoite
Language English
Date 1999-01-15
Published in Acta Tropica. Amsterdam: Elsevier B.V., v. 72, n. 1, p. 13-24, 1999.
ISSN 0001-706X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 13-24
Origin http://dx.doi.org/10.1016/S0001-706X(98)00078-3
Access rights Closed access
Type Article
Web of Science ID WOS:000078036600002
URI http://repositorio.unifesp.br/handle/11600/26026

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