Risk factors for severe hemorrhagic cystitis following BMT

Risk factors for severe hemorrhagic cystitis following BMT

Author Seber, Adriana Autor UNIFESP Google Scholar
Shu, X. O. Google Scholar
Defor, T. Google Scholar
Sencer, S. Google Scholar
Ramsay, N. Google Scholar
Institution Univ Minnesota
Universidade Federal de São Paulo (UNIFESP)
Childrens Hlth Care
Abstract Hemorrhagic cystitis (HC) is a common toxicity of preparative regimens for bone marrow transplantation (BMT), Severe HC often requires prolonged and expensive hospitalization, and occasionally can result in death. To investigate the risk factors for severe HC, we conducted a retrospective study among 1908 patients who received BMTs at the University of Minnesota during 1974 to 1993, A previous report from our institution reported on 977 of these patients. We identified all patients with genitourinary complication within 100 days post-BMT from the BMT database. Medical charts for these patients were reviewed to determine whether the patient had HC and also the grade of HC, A total of 208 HC cases were identified during the study period. of them, 92 patients had severe HC, an incidence of 5% (95% CI = 4-6%), We found that grade II-IV graft-versus-host disease (RR = 2.56; 95% CI = 1.43-4.56), use of busulfan (RR = 2.69; 95% CI = 1.35-5.35), and age at transplant (RR = 2.20; 95% CI = 1.27-3.81, for age of 10-30 compared to age of 0-9) were related to an increased risk of HC. in contrast, transplant year was inversely associated with the risk of HC (trend test, P < 0.01). We did not find any significant difference in HC with the use of prophylactic Mesna.
Keywords bone marrow transplantation
hemorrhagic cystitis
risk factors
Language English
Date 1999-01-01
Published in Bone Marrow Transplantation. Basingstoke: Stockton Press, v. 23, n. 1, p. 35-40, 1999.
ISSN 0268-3369 (Sherpa/Romeo, impact factor)
Publisher Stockton Press
Extent 35-40
Origin http://dx.doi.org/10.1038/sj.bmt.1701523
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000078318800006
URI http://repositorio.unifesp.br/handle/11600/25997

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