PARTICIPATION of the ADRENAL-GLAND in the ANTIINFLAMMATORY EFFECT of POLYUNSATURATED DIETS

PARTICIPATION of the ADRENAL-GLAND in the ANTIINFLAMMATORY EFFECT of POLYUNSATURATED DIETS

Author Silveira, Vera Lucia Flor Autor UNIFESP Google Scholar
Limaos, E. A. Google Scholar
Nunes, D. W. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract THE effect of an n-3 (fish) and n-6 (soybean) fatty acid-rich diet on carrageenin paw oedema in rats, and the participation of adrenal gland, corticosterone and alpha(2)-macroglobulin (alpha(2)-M) in this process were studied. A significant inhibition of carrageenin oedema was observed not only in rats fed a diet rich in fish oil but also in the soybean group. alpha(2)-M was not detectable before carrageenin injection, suggesting that this putative anti-inflammatory factor does not participate in the observed anti-inflammatory effect. Corticosterone levels were higher in fat-fed than in control rats, before carrageenin stimulus and adrenalectomy abolished the anti-inflammatory response in fat-fed animals, showing the important role of the adrenocortical hormones in this process.
Keywords CARRAGEENAN EDEMA
CORTICOSTEROIDS
ALPHA(2)-MACROGLOBULIN
POLYUNSATURATED FATTY ACIDS
Language English
Date 1995-09-01
Published in Mediators of Inflammation. London: Rapid Science Publishers, v. 4, n. 5, p. 359-363, 1995.
ISSN 0962-9351 (Sherpa/Romeo, impact factor)
Publisher Rapid Science Publishers
Extent 359-363
Origin http://dx.doi.org/10.1155/S0962935195000585
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1995TC00200008
URI http://repositorio.unifesp.br/handle/11600/25522

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