TYPE-I BIPOLAR DISORDER ASSOCIATED WITH A FRAGILE SITE ON CHROMOSOME-1

TYPE-I BIPOLAR DISORDER ASSOCIATED WITH A FRAGILE SITE ON CHROMOSOME-1

Author Turecki, G. Google Scholar
Smith, MDAC Google Scholar
Mari, J. J. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The objective of this paper is to study the association between chromosomal fragile sites and type I bipolar disorder, This case-control study compares bipolar patients with normal controls, Ten cases of type I bipolar disorder diagnosed according to DSM-III-R criteria and the Composite International Diagnostic Interview (CIDI) were selected from the Escola Paulista affective disorders outpatient clinic and 10 healthy controls (CIDI negative for psychiatric diagnoses) matched for sex and age were drawn from the otorhinolaryngologic outpatient clinic of the same hospital, the cytogenetic analysis was carried out with blood lymphocytes, which were cultured in a folic acid-free medium. A total of 100 mitoses per subject were blindly analyzed to the psychiatric diagnostic assignment, and fragile sites were identified according to a minimum expected frequency of events per band in conformity with a Poisson distribution. A higher frequency of chromosomal lesions for cases than controls was found for the following bands: 1q32, 5q31, and 11q23, the 1q32 being considered a fragile site. Although no evident neuropsychiatric etiological component has been mapped to the 1q32 region so far, this finding may lead to further investigation of a possible linkage between genetic markers of this region and bipolar disorder, (C) 1995 Wiley-Liss, Inc.
Keywords CASE-CONTROL STUDY
CYTOGENETICS
AFFECTIVE DISORDERS
Language English
Date 1995-06-19
Published in American Journal of Medical Genetics. New York: Wiley-liss, v. 60, n. 3, p. 179-182, 1995.
ISSN 0148-7299 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 179-182
Origin http://dx.doi.org/10.1002/ajmg.1320600302
Access rights Closed access
Type Article
Web of Science ID WOS:A1995RD83900001
URI http://repositorio.unifesp.br/handle/11600/25506

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