EFFECT of VALEPOTRIATES ON the BEHAVIOR of RATS in the ELEVATED PLUS-MAZE DURING DIAZEPAM WITHDRAWAL

EFFECT of VALEPOTRIATES ON the BEHAVIOR of RATS in the ELEVATED PLUS-MAZE DURING DIAZEPAM WITHDRAWAL

Author Andreatini, R. Google Scholar
LEITE, JR Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The effect of a mixture of valepotriates on the elevated plus-maze performance of diazepam withdrawn rats was evaluated. the rats were chronically (28 days) treated with diazepam (doses increased up to 5.0 mg/kg) and then treated with control solution for 3 days to induce a withdrawal syndrome. Chronically vehicle-treated rats were used as control. the abstinent animals treated with vehicle showed a significant decrease in the percentage of time spent in the open arms when compared with the control animals. Diazepam and valerian 12.0 mg/kg reversed this anxiogenic effect. Valerian 6.0 mg/kg did not show any difference in relation to the others group.
Keywords ANIMAL MODEL
ANXIETY
BENZODIAZEPINE WITHDRAWAL
ELEVATED PLUS-MAZE
VALEPOTRIATE
Language English
Date 1994-08-01
Published in European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 260, n. 2-3, p. 233-235, 1994.
ISSN 0014-2999 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 233-235
Origin http://dx.doi.org/10.1016/0014-2999(94)90342-5
Access rights Closed access
Type Article
Web of Science ID WOS:A1994PA77900017
URI http://repositorio.unifesp.br/handle/11600/25423

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