DECREASED MUSCARINIC RECEPTOR-BINDING in RAT-BRAIN AFTER PARADOXICAL SLEEP-DEPRIVATION - AN AUTORADIOGRAPHIC STUDY

DECREASED MUSCARINIC RECEPTOR-BINDING in RAT-BRAIN AFTER PARADOXICAL SLEEP-DEPRIVATION - AN AUTORADIOGRAPHIC STUDY

Author Nunes, G. P. Google Scholar
Tufik, S. Google Scholar
Nobrega, J. N. Google Scholar
Institution CLARKE INST PSYCHIAT
Universidade Federal de São Paulo (UNIFESP)
Abstract Previous work demonstrated that paradoxical sleep deprivation (PSD) leads to a decrease in yawning behavior elicited by cholinergic agonists, suggesting that a downregulation of cholinergic muscarinic receptors may occur after PSD. More recent work using intracerebral injections of muscarinic agonists has suggested a critical role for M2 receptors in paradoxical sleep. in this study [H-3]AF-DX 384 was used to investigate the effects of PSD on M2-type cholinergic receptors throughout the brain using quantitative autoradiography. After 96 h of paradoxical sleep deprivation, [3H]AF-DX 384 binding was generally reduced throughout the brain, and significantly so in the olfactory tubercle (-20%), n. accumbens (-23%), frontal caudate-putamen (-16%), islands of Callejas (-20%), piriform cortex (-24%), lateral (-26%) and medial (-24%) septum, anteromedial (-19%), ventrolateral (-22%), and lateral geniculate (-15%) nuclei of thalamus, deep layers of the superior colliculus (-15%), entorhinal cortex (-12%) and subiculum (-23%). [H-3]AF-DX 384 binding was reduced in pontine structures, but not to a higher degree than in other brain areas. the observed downregulation of M2-type muscarinic receptors after PSD may be causally related to the previously reported decrease in cholinergically induced behaviors after PSD.
Keywords PARADOXICAL SLEEP DEPRIVATION
RAT
BRAIN MUSCARINIC M2 RECEPTOR
ACETYLCHOLINE
[H-3] AF-DX 384
Language English
Date 1994-05-09
Published in Brain Research. Amsterdam: Elsevier B.V., v. 645, n. 1-2, p. 247-252, 1994.
ISSN 0006-8993 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 247-252
Origin http://dx.doi.org/10.1016/0006-8993(94)91658-6
Access rights Closed access
Type Article
Web of Science ID WOS:A1994NK54000028
URI http://repositorio.unifesp.br/handle/11600/25408

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